WS-383 is a potent, selective, and reversible small-molecule inhibitor of the DCN1-UBC12 protein-protein interaction (IC50 = 11 nM). In cellular assays it inhibits Cul3/1 neddylation and induces accumulation of p21, p27, and NRF2. Supplied as a solid with high purity for research use.
- Potent DCN1-UBC12 inhibitor (IC50 = 11 nM).
- Reversible inhibition of the DCN1-UBC12 interaction.
- Inhibits Cul3/1 neddylation in cellular assays.
- Induces accumulation of p21, p27, and NRF2.
- High purity suitable for research applications.
- Solid form with defined storage recommendations.
- Molecular weight 498.46 g·mol⁻1; formula C18H21Cl2N9S2.